Papers

2018 – LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

2016 – Identification of chromatin accessibility domains in human breast cancer stem cells

2016 – Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation

2016 – Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer

2015 – PKC-theta is a novel sc35 splicing factor regulator in response to T cell activation

2015 – Protein kinase C in the immune system: from signalling to chromatin regulation

2015 – Multi-Layered Epigenetic Regulatory Mechanisms Mediate Epithelial to Mesenchymal Transition in Cancer

2014 – Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation

2014 – Chromatinized Protein Kinase C- Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells

2011 – Chromatin-Associated Protein Kinase C-q Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes

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There is a substantial un-met clinical need when it comes to fighting recurrent, metastatic breast cancer. This is the major cause of death in women with breast cancer. We aim to address that unmet need by the novel targeting of breast cancer stem cells, which are resistant to conventional systemic anticancer therapies and therefore contribute to the failure of these therapies in patients.

Professor Sudha Rao

Founder & Director at EpiAxis Therapeutics

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